TECHNOLOGY
Live Attenuation Platform
KHAV develops vaccines for human and animal diseases using the Live Attenuation Platform
Technical Description Schematic
Live Attenuationis a technique to recover the pathogenicity of bacterial or viral pathogens using techniques such as passaging.
- Attenuated pathogen can replicate in host and induce immunity but cause symptoms.
- Attenuated vaccines use the same mechanisms as natural infection to ensure multiple routes of immunisation and activate the immune system, including cellular immunity, to defend against foreign pathogens.
Live Attenuation Platform
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Pathogen -
Immunogenicity and safety study
after applying live attenuation platform -
Live attenuated vaccine
KHAV’s Strength
- KHAV can develop live attenuated vaccines quickly and safely using its own heat-treatment technology.
Heat treatment technology features
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serial passages Heat treatment Incubation -
Temperature-sensitive mutant -
Verification of vaccine
candidate using animal model
(Safety & Efficacy)
Strength of live attenuated vaccine
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Activation of cellular immunity
Activation of local immunity -
Various inoculation routes
Platform Applications
Animal Health
We are developing a region-specific attenuated live vaccine to counteract domestic and international outbreaks of avian infectious bronchitis virus.
Human Health
We are using our experience in developing an attenuated live vaccine for chicken infectious bronchitis virus to develop an attenuated live vaccine for the human COVID-19 virus.
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serial passages -
Verification of vaccine candidate using animal model
(Safety & Efficacy) -
Vaccine Virus